
From 1550 onwards, several physiologists of the Paduan school, including Matteo Colombo, Carpi and Hieronymus Fabricius of Aquapendente, studied the problem. William Harvey based his work on that of his predecessors and had the inspired idea of considering the heart as a pump that was operated by muscular pressure. Proof of the existence of capillary vessels linking the arterial and venous systems was supplied in 1661 by the anatomist Marcello Malpighi (Italy). (Inventions and Discoveries)