
The bacteria that live in the human mouth are not normally harmful, but if they are not removed by brushing, they can build up into a thin layer. Then the bacteria nearest the tooth surface begin to metabolize food with anaerobic respiration (without oxygen); the waste ducts of that process are very acidic.
Daily brushing, flossing, and use of mouthwash are the primary preventative methods. Dentists can remove plaque in a process called scaling, if gum disease is present, root planting is utilized. (All Facts Considered, by Kee Malesky)